# saemixPBPK

**Version:** 1.3.0  
**License:** GPL (>= 2)

## Overview

**saemixPBPK** is an R package that implements the Stochastic Approximation Expectation Maximization (SAEM) algorithm
for PBPK/QSP models developed with the OSP Suite. This package enables robust and efficient estimation procedures for
pharmacokinetic and quantitative systems pharmacology modeling.

## Features

- Estimation using the SAEM algorithm for PBPK/QSP models.
- Designed to work with models developed in the OSP Suite.
- Visualization and diagnostic tools.
- Support for simulation and model evaluation workflows.

## Authors

- Donato Teutonico ([Maintainer](mailto:donato.teutonico@gmail.com))
- Marc Lavielle
- Emmanuelle Comets
- Lucas Bodelle

## Installation

Please use the latest release file available on GitHub or
to test the development versionuse the following code to install from GitHub:

```R
# If devtools is not installed, install it first
install.packages("devtools")

# Install saemixPBPK from GitHub
devtools::install_github("Sanofi-Public/saemixPBPK")

Dependencies

• graphics
• stats
• methods
• gridExtra
• ggplot2
• grid
• rlang
• abind
• progress

Documentation

Documentation is provided within the package. Use help(package = "saemixPBPK") in R to see available functions and their documentation.

Contributing

Contributions are welcome. Please open an issue or pull request for bugs, feature requests, or improvements.

License

This package is licensed under GPL (>= 2).